On May 6, 2018, during Tenacious D's performance at the Shaky Knees Music Festival, Black asked the audience if anyone had seen The Pick of Destiny, and that "part two is coming out in October. I don't know where you'll be able to see it, but we've decided it's happening and it's coming out. Rocktober".
On May 15, 2018, the band updated their website and social media platforms with drawings from the series, as well as announcing a 2018 fall US tour through a tour trailer, and releasing new merchandise. On September 4, it was announced that the series would be released on YouTube, with the first episode coming out on September 28. A new episode was released every Friday from then until November 2, to mark the release of the Post-Apocalypto album and the subsequent tour.
The series was screened at the LA Film Festival on September 24, the Fantastic Fest on September 25, the L.A. Comic Con on October 26, across the Alamo Drafthouse Cinema chain on November 2 and at the Prince Charles Cinema in London on May 31, 2019. It was praised for its commentary on toxic-masculinity and toxic-feminism, , and music.