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Jane Murfin, née Macklem (October 27, 1884 – August 10, 1955) was an American playwright, director and screenwriter. The author of several successful plays, she wrote some of them with actress Jane Cowl—most notably Smilin' Through (1919), which was adapted three times for motion pictures. In Hollywood Murfin became a popular screenwriter whose credits include What Price Hollywood? (1932), for which she received an Academy Award nomination. In the 1920s she lived with Laurence Trimble, writing and producing films for their dog Strongheart, the first major canine star.

Jane Macklem was born October 27, 1884, in Quincy, Michigan. In 1907 she married attorney James Murfin, and retained his surname when the marriage ended fewer than five years later.

Murfin began her career with the play Lilac Time, which she co-wrote with actress Jane Cowl. The Broadway production opened February 6, 1917, and ran for 176 performances. Later that year the two women began collaborating, often under pseudonym Allan Langdon Martin, on a series of revivals of World War I melodramas. The pair later collaborated on Daybreak, followed by Information Please (1918) and Smilin' Through (1919).

In Hollywood, Murfin became a leading screenwriter, writing many romantic comedies and dramas by herself or in collaboration.

In 1920, director Laurence Trimble persuaded Murfin to purchase a German Shepherd dog—Strongheart—that became the first major canine film star. Strongheart starred in four films that Trimble directed from Murfin's screenplays: The Silent Call (1921), Brawn of the North (1922), The Love Master (1924) and White Fang (1925).

Murfin is credited with directing one film, Flapper Wives (1924), before the dissolution of her partnership with Trimble. Film historian Kevin Brownlow described this partnership as both professional and personal; although some sources describe Trimble and Murfin as a husband-and-wife filmmaking team, no marriage has been substantiated.

Murfin's later screenwriting credits include Way Back Home (1931), Our Betters (1933), The Little Minister (1934), Spitfire (1934), Roberta (1935), Alice Adams (1935), The Women (1939), Pride and Prejudice (1940), and Dragon Seed (1944).

Murfin was married first to lawyer James Murfin from 1907 to 1912. Her second marriage was to actor Donald Crisp, for whom she would write parts in her scripts; the marriage lasted from 1932 to 1944.

Murfin and Adela Rogers St. Johns were nominated for the Academy Award for Best Story for What Price Hollywood? (1932). Frances Marion received the award for The Champ.

Murfin is credited as a writer; additional production credits are noted.