主演女優賞（コメディ・シリーズ部門）

This is a list of winners and nominees of the Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series. Beginning with 1966, leading actresses in comedy have competed alone. However, these comedic performances included actresses from miniseries, telefilms, and guest performers competing against main cast competitors. Such instances are marked below:# – Indicates a performance in a Miniseries or Television film, prior to the category's creation § – Indicates a performance as a guest performer, prior to the category's creation