Lowe made his TV debut in 1981 in Thames Television's Theatre Box. On stage, he played Wharton in "Another Country" at the Queen's Theatre, Shaftesbury Avenue, London. In 1983 he played Young Edmond Bertram in BBC 1's Mansfield Park. His career has included diverse roles from serious drama to character comedy. He has worked as both a writer and actor in many different areas of media.
In 1990, Lowe appeared in The Hypochondriac at the Edinburgh Fringe Festival and won a First.
In 1991, having trained at The Studio School in North London and Leicester School of Performing Arts, he played PC Corman in Minder alongside George Cole. Lowe has appeared in a variety of different television programmes, including, Three Men in A Boat, The Rise and Fall of Rome, The Fast Show, Fun at the Funeral Parlour, The Big Impression Christmas Special, and Bremner, Bird and Fortune. He appeared in four episodes of Simon Day's comedy series Grass as precocious child star Crispin Winterville's father Roland. He played Clinton Baptiste in Peter Kay's Phoenix Nights and Sparky in That Peter Kay Thing. He starred with Lee on The 11 O'Clock Show on Channel Four in the late 1990s, usually appearing as a reporter. In 2007, he wrote and performed for Ronni Ancona and Co. for BBC One and performed in The Peter Serafinowicz Show on BBC 2.
In the cinema, Lowe played Paul in Peter's Friends, The Messenger in Much Ado About Nothing and Simon Merriel in Haunted.
On radio, Lowe has appeared on Absolute Power, 15 Minute Musical, Not Today, Thank You, The Laxian Key and The Scarifyers; he plays Brian in Clare in the Community for BBC Radio 4. Lowe has also appeared twice on Loose Ends on BBC Radio 4 with Iain Lee, Big Brother's Big Mouth and Sam Delaney's Stupid Telly (as Barry from Watford). From 2001 to 2003 he hosted Download This for XFM London on Sunday mornings from 10 am to midday.
On 12 October 2008, he reprised his role as Clinton Baptiste in Peter Kay's Britain's Got The Pop Factor ... And Possibly A New Celebrity Jesus Christ Soapstar Superstar Strictly On Ice, a spoof on talent show programmes.
On 22 May 2009, he appeared on BBC Radio 2's Steve Wright in the Afternoon show, talking about his life. He also talked about being a lifestyle guru. He became a regular weekly contributor to the programme.
In April 2010, he recorded a comedy pilot for BBC Radio 2 The Alex Lowe Double Act with impressionist Alistair McGowan. It was broadcast on 15 May 2010.