Lathan began directing network television in 1973, when he was brought to Los Angeles to direct multiple episodes of Sanford & Son. He went on to direct Hill Street Blues, Miami Vice, Remington Steele, Cagney & Lacey, Frank's Place, Roc and others. He also directed the 1984 feature film Beat Street for Orion Pictures.
In 1989, Lathan partnered with Russell Simmons to create the stand-up comedy franchise Def Comedy Jam on HBO. This series ran for 8 seasons and showcased many of today's popular television & movie stars. Lathan received a Peabody Award for the series Def Poetry on HBO in 2003. That same year, Lathan co-produced Def Poetry Jam on Broadway, which won a Tony Award for best special theatrical event and has toured both domestically and internationally.
Lathan has directed the pilots for many sitcoms, including Martin, Moesha, The Parkers, The Steve Harvey Show, Amen, South Central, Cedric the Entertainer Presents, All of Us, Eve, The Soul Man and Real Husbands of Hollywood.
Lathan was the executive producer and director of the stand-up comedy special Dave Chappelle: Killin' Them Softly written by and starring comedian Dave Chappelle. It was Chappelle's first hour-long HBO special, and premiered in 2000. Lathan would go on to produce and direct several more of Chappelle's specials, including For What It's Worth, which was produced in 2004 for Showtime. In 2017, Lathan produced and directed four Chappelle specials for Netflix: The Bird Revelation, Equanimity, The Age of Spin, and Deep in the Heart of Texas. He also produced and directed Chappelle's fifth Netflix special, Sticks & Stones, which was released in 2019.
He executive produced and directed Cedric the Entertainer: Taking You Higher, a one-hour comedy special for HBO, and It's Black Entertainment, a two-hour musical documentary for Showtime.
Lathan directed dramas for public television's Great Performances, American Playhouse and The American Short Story. For PBS, he directed Alvin Ailey: Memories & Visions and other dance specials featuring the Martha Graham Company, Mikhail Baryshnikov and Agnes de Mille. He directed three seasons of the popular PBS music series, SOUL!, and he was one of the first directors of Sesame Street.
In 2006, Lathan co-created Run's House, a five-season reality series for MTV that spawned a spinoff series, Daddy's Girls. He also co-executive produced Running Russell Simmons, an eight-part series for Oxygen. In 2012, he executive produced and directed The Ruckus, a stand-up series for Comedy Central.