The Hoboken High School Redwings compete in the Hudson County Interscholastic League, which is comprised of public and private high schools in Hudson County, operating under the supervision of the New Jersey State Interscholastic Athletic Association (NJSIAA). With 328 students in grades 10–12, the school was classified by the NJSIAA for the 2019–20 school year as Group I for most athletic competition purposes, which included schools with an enrollment of 75 to 476 students in that grade range. The football team competes in the National Red division of the North Jersey Super Football Conference, which includes 112 schools competing in 20 divisions, making it the nation's biggest football-only high school sports league. The school was classified by the NJSIAA as Group II North for football for 2024–2026, which included schools with 484 to 683 students.
The school participates as the host school / lead agency in a joint girls lacrosse team with Weehawken High School. In turn, Weehawken is the host school for a joint boys lacrosse team. These co-op programs operate under agreements scheduled to expire at the end of the 2023–24 school year.
Hoboken High School offers over 24 athletic programs with over 30% student participation. Interscholastic sports offered at the school include:
Fall:
Football: Varsity, Junior Varsity, Freshman
Boys' Soccer: Varsity, Junior Varsity
Girls' Soccer: Varsity, Junior Varsity
Girls' Tennis: Varsity, Junior Varsity
Girls' Volleyball: Varsity, Junior Varsity
Boys' and Girls' Cross Country Track: Varsity
Cheerleading: Varsity
Strutters: Varsity
Winter:
Boys' Basketball: Varsity, Junior Varsity, Freshman
Girls' Basketball: Varsity
Boys' and Girls' Swimming: Varsity
Boys' and Girls' Bowling: Varsity
Boys' and Girls' Indoor Track: Varsity
Cheerleading: Varsity