Jason Anderson, former Major League Baseball relief pitcher (2003–05)
Irving Azoff, personal manager to several notable musical talents; former head of MCA Records; producer of several films (Fast Times at Ridgemont High); Chairman of Ticketmaster
Kenneth D. Bailey, major in the United States Marine Corps; posthumously awarded the Medal of Honor for his actions at Matanikau River during the Battle of Guadalcanal in 1942; namesake of destroyer USS Kenneth D. Bailey
William B. Black, member of the Illinois House of Representatives (1986–2010)
Keon Clark, former NBA basketball player (1998–2004); selected in the first round of the 1998 NBA draft
Laurie Perry Cookingham (1896–1992), city manager of multiple cities, including Kansas City, Missouri and Fort Worth, Texas
Gene Hackman, Academy Award-winning actor, best known for his work in film (The French Connection, Unforgiven)
Ned Luke, actor, Grand Theft Auto V
Justin March-Lillard, NFL linebacker
Greg Meidel, television producer
John P. Meyer, Illinois state legislator and judge
Donald O'Connor, Emmy Award-winning actor and dancer, perhaps best known for his role in the film Singin' in the Rain
Julian Pearl, college football offensive tackle for the Illinois Fighting Illini
Bill Putnam, audio engineer, songwriter, producer, studio designer and businessman, who has been described as "the father of modern recording"
Scott Shaw, photojournalist; received the 1988 Pulitzer Prize for spot news photography
Trent Sherfield, wide receiver for the Minnesota Vikings
Bobby Short, singer and musician known for his interpretations of early 20th-century American music, and for promoting the compositions of African American composers
Sterling Slaughter, former MLB player (Chicago Cubs)
John W. Speakman, Illinois state legislator and lawyer