After 34 years of inactivity, David Fenton, Ed Bazalgette, and Steve Smith appeared on stage at the Half Moon in Putney on 30 April 2016. With a guest drummer standing in for Howard Smith, they played "Turning Japanese" and then left the stage. Rumors of a reunion were rife, and the Vapors completed a four-date tour in October–November 2016 with Michael Bowes on drums. The Vapors continued with six more concerts in 2017 and 10 in 2018. That included three dates in New York City with David Fenton's son, Danny, standing in for Ed Bazalgette on lead guitar, where they played several new tracks, including "Sundown River", "Letter to Hiro (No11)", "The Right Stuff", "One of My Dreams", and "King L".
As of 2017, the band's catalogue masters are controlled by Razor & Tie Industries, which acquired them from Warner Music Group, whose Alternative Distribution Alliance serves as RT Industries' worldwide distributor when RT was newly launched in 2018. On 21 April 2018, they re-released "Turning Japanese" on red vinyl with bonus tracks for Record Store Day.
In April 2019, the band was announced as the support to From the Jam on the 30-date Setting Sons 40th Anniversary tour. The Vapors had been the opening act for The Jam on the original 1979 Setting Sons tour. Bazalgette left the band around that time and was replaced by Danny Fenton.
On 3 March 2020, the Vapors announced that they would be releasing a new album, Together, and issued "Crazy" as its lead single. Together was released on 15 May. It was the first album from the Vapors in 39 years, marking one of the longest gaps between studio albums.
On 30 August, "Girl from the Factory", the third single from the album, reached number one on the United DJs Heritage Chart. Follow-up single "Wonderland" also reached the top of the Heritage Charts on 22 November.
The band celebrated their top-selling album by going out on the New Clear Days 40th Anniversary Tour in 2021. The download-only singles "One of My Dreams Came True" (2021), "Novocaine" (2022), and "Eyes on the Prize" (2024) all reached the Heritage Chart top ten, maintaining the band profile.
On 2 September 2022 the band returned to their Guildford roots to play at the town's Suburbs Holroyd Arms.
In January 2023, a US show was announced: the band played at the Cruel World Festival in Pasadena, California on 20 May 2023.
In August 2024, the band announced plans to crowdfund the production of their fourth album. The album, Wasp in a Jar, was released on 28 February.