The story begins with two brothers William (Elder) and Henry, as they leave their native town and travel to London, following the death of their father, a country shopkeeper. Both brothers are under twenty years old, and hope to acquire a living in London. It would appear they are not financially secure as 'through death, their father escaped his creditors'. As they travel Henry weeps, while William does his best to suppress tears. They arrive in London and soon find every attempt to secure employment is met with obstacles. However, there is one thing Henry can do, which is to play the fiddle. Once this becomes known, Henry is invited into company that enables his advancement. He is overjoyed, but also unable to fully enjoy his situation while his brother has not secured a living. Henry offers to teach William to play the violin, but his offer is vehemently refused by his brother. They both agree that he William is much more adept to learning academia than music, so Henry suggests William should go to one of the universities to study.
William manages to attend university with the help and support of Henry, who has sustained a good living through his violin playing. Henry continues to mix with those in wealthy upper-class circles, and through enjoyment of his playing by one man, he manages to secure a living of five hundred pounds for his brother on the man's death. William succeeds in his studies, obtaining the orders of dean and priest. By now the wealthy man has died and William wastes no time returning to take possession of this good fortune. On seeing his brother dressed up in his orders attire, Henry cries tears of pride and joy. However, being the elder, a man of literature, William feels contempt at being obliged to a younger illiterate sibling, and is unable to show gratitude towards Henry. This also makes William feel contempt for his own ingratitude. As Henry's fame and position increases, William seeks advancement within the church. Once he secures position of dean, William begins to insult Henry for his 'useless occupation', highlighting the shame it brings on him in his position of dean. No longer feeling worthy of his brother's company, Henry decides to marry in the hope of finding a companion and friend better suited to his own position.
Henry does find a wife, when William hears and discovers she is a singer, they argue. William refuses to accept Henry's wife, or introduce her to his own wife Lady Clementina. The brothers are estranged for over a year, when William hears of the death of Henry's wife. Unsure of how he should conduct himself, William seeks the advice of his wife, who informs him, with Henry being the inferior, it should be Henry alone to be the first to seek reconciliation. At first William agrees, however constant exposure to Lady Clementina's vanity and selfishness, causes him to reflect on his previous behaviour, and he proceeds to seek Henry out. He finds that Henry has in fact left England for Africa, with his son, following the death of his wife. Time passes, and William and his wife have a child, a boy also named William, who is doted on by his father and educated in the manner equal to his high position in society.