Domina was well received. Spencer Perry of ComicBook.com expressed that her fashional presentation brought a unique visible style that had been absent in Overwatch, and called her "built not only on being chic in appearance, but also never getting her hands dirty". Chaping XPIN via the Tencent news portal expressed their surprise at her appearance and popularity, stating that while a good looking character will not immediately retain players on its own, it certainly drew attention. They further called her overall well designed, and questioned if Blizzard had poached artists from competing hero shooter Marvel Rivals. Jade King of TheGamer stated that while she was critical of some of the design choices of Overwatch characters, she felt Domina illustrated progress in being portrayed as an incredibly strong and confident Indian woman who "owned her looks" like previously successful Overwatch female characters, and further wanted to see more characters "across the spectrum of culture and attraction that don’t fill the same predictable demographic".
The staff of Chinese media outlet GamerSky.com attributed Overwatch's renewed popularity in part to her introduction as a "dark skinned mature woman". They further described her as having a "mature and charismatic 'voluptuous older sister' style" and a figure "full of strength", while stating that elements such as her "Heartbreaker" emote cosmetic suggested she had a rare tender side that resonated with fans. They further observed how some fans viewed characters like Domina as part of a renewed focus by Blizzard to develop traditionally attractive characters, with mixed response. Noting the company had previously been praised for pushing back against female character stereotypes, they suggested such a shift may have been due to Rival's success, citing fan comparisons of Domina to its depiction of Emma Frost.
Domina's sex appeal became a popular subject amongst players, resulting in a large amount of fan art and videos. Chaping XPIN noted that upon release her character model was almost immediately extracted for use in community generated pornography, while third-party figure company PA Created Studio developed a statue of the character featuring an eroticized design. Kaan Serin of GamesRadar+ stated that during the game's "Conquest" event, a faction war event where players would support either Overwatch or Talon in weekly batches, the latter saw overwhelming support from players hoping to secure in-game cosmetics for the character. He attributed it to players being "down bad" for the character, a which he describe as "shady business exec with a sassy mouth and, as the name suggests, a moveset capable of dominating tight spaces" that he felt further encouraged much of her fan art.