Paris, France
The year is 1887, Van Helsing is in Paris pursuing Dr. Jekyll after he had murdered several men, women, children, goats, and poultry. Prior to confrontation, Dr. Jekyll, using the attic of Notre-Dame de Paris as a lab and a hideout, drank a concoction to transform to Mr. Hyde, becoming bigger, stronger, faster and retaining his memory. Just prior to the ensuing conflict, Mr. Hyde teases Helsing as to him chasing his memories, conveying history between the two and to Helsing not knowing his past. Helsing battles with and ultimately defeats Mr. Hyde by throwing him out of the window of the church. He is assigned to pursue Dracula by the Holy Order, to track down a woman named Anna Velarious, as she can help, but is warned of the outnumbering dead.
St. Peter's Basilica, Vatican
Van Helsing is tasked with tracking down and eliminating evil by the aforementioned Holy Order, headquartered in the Vatican. He is doing this in hopes of correcting forgotten sins and to regain memory. The Order has been protecting humankind "since time immemorial", as said by Cardinal Jinette, the one giving orders to Van Helsing. His next focus is in a town called Vaseria in Transylvania.
Vaseria, Transylvania
After arriving at the train station outside of Transylvania a ghost appears, almost as if asking to be followed. Outside the town of Transylvania he is accosted by skeletons come back to life. After clearing the town of once again living skeletons, Helsing goes to the fountain, where he discovers a large pale man is interwoven cloth robes. This large powerful man attacks the protagonist, but later escapes.
Vaseria Villiage, Transylvania
Van Helsing is tasked to go to a place "most holy and divine", as called by Cardinal Jinette. Upon entering the church he discovers 4 women, three of which are of an unfriendly nature, one is revealed to be Anna Velarious. The three ladies are the Brides of Dracula, who address Van Helsing as if they know him well, leaving him confused as he has no recollection. After defeating one of the women, who turns out to be a vampire close to Dracula, a Bride of Dracula named Marishka, Anna awakens. She was tracking down her missing brother who was bitten by a werewolf and since vanished. She guides Helsing to the library where Velkan was studying Dracula before his disappearance.
Woods, Transylvania