Frontman Chris Goss started out with a band covering heavy 1970s rock acts (New York Dolls, Aerosmith, David Bowie, Blue Öyster Cult, Alice Cooper, Led Zeppelin) and writing his own songs since circa 1975. After getting into punk rock for a while (performing at CBGB in 1978), he did not play guitar for a few years, instead preferring electronic music like Kraftwerk and becoming a club DJ.
In 1981 Goss and Tim Harrington started to make experimental home recordings with lo-fi, cheap and/or borrowed equipment that included a Sanyo boombox Rhythm Ace drum machine, a Korg, synthesizers and a Fender Vibroverb amp. The rhythm tracks of synths and a beat recorded on cassette would be played back to "overdub" vocals, guitar, more synthesizers, et cetera. They considered Manson Family as a name for their act, but never actually used it for their performances. They played regularly at CBGB with a sound reminiscent of Suicide or somewhat like how Nine Inch Nails or Marilyn Manson would sound in the 1990s.
Early original songs included "Building the Kingdom", "Voodoo Doll", "Metal Entity", "Cash", "Anchor", "Stones in Every Field" and "Doraldina's Prophecies".
Masters of Reality grew into a four-piece with the addition of Googe (bass) and Vinnie Ludovico (drums) and developed a sound with less electronics and more heavy blues rock with influences like Black Sabbath, Cream, Led Zeppelin and King Crimson. A demo tape reached producer Rick Rubin who went to see a live show in late 1986 and then signed the band to Def Jam. Rubin brought out the blues rock character of the band Rubin quit Def Jam but took the band with him to his new Def American label, before their self-titled debut album was eventually released in 1989.
The band appears briefly in the 1990 film Marked for Death (starring Steven Seagal).
Goss got frustrated with the band while touring the debut album. He quit the tour after Matt Dike invited him to come to Los Angeles and to get signed to his Delicious Vinyl label. They bought the rights from Rubin and released a newly sequenced version of the album with "Doraldina's Prophecies" as an extra track.
In 1992 Goss and Googe resurfaced, now with Ginger Baker (formerly of Cream) on drums. The new album Sunrise on the Sufferbus spawned a Top 10 rock chart hit with the single "She Got Me (When She Got Her Dress On)". An album cut sometimes used by American radio shows when they have a British guest is "T.U.S.A.", a rap by Baker describing the inability of Americans to make a proper cup of tea.