Michael Steadman (Ken Olin) and Hope Murdoch Steadman (Mel Harris): Hope is from Philadelphia, and Michael is from Chicago but remained in the Philadelphia area after graduating from the University of Pennsylvania. Hope is a graduate of Princeton and a consumer affairs writer. After having their daughter Janie, Hope becomes a stay-at-home mother and initially gives up her writing. Later, she returns to work but struggles with her role as a mother in the process. During a difficult period in her marriage when she is pregnant with her second child, Leo, Hope contemplates having an affair with environmentalist John Dunaway (JD Souther). Michael's confrontation with her over this leads them to resolve their problems and rekindle their marriage. Michael is Jewish, and Hope is Christian, and complications from their interfaith marriage recur throughout the series. Michael's original ambition was to be a writer, but he works in advertising with graphic designer Elliot. The men first meet at the Bernstein Fox ad agency and then leave to form The Michael and Elliot Company. When their company goes bankrupt, Michael and Elliot join the advertising corporation DAA, run by Miles Drentell. Michael's relationship with Miles erodes his marriage with Hope, who finally decides to accept a job in Washington, D.C. By the time the show was canceled, Michael had decided to quit work altogether so that Hope could pursue her own interests.
Elliot Weston (Timothy Busfield) and Nancy Krieger Weston (Patricia Wettig): Elliot studied graphic design at Rhode Island School of Design (RISD). His father Charlie (Eddie Albert) is divorced from Elliot's mother and now lives in California. Elliot's sister Ruthie (played by Meagen Fay), who lives in Philadelphia and is married with two children, has not forgiven their father for leaving them. Elliot works in the advertising business with Michael (initially in their own business, but later for DAA). Nancy was also an art major and is a stay-at-home mother to Ethan and Brittany. Like Hope, she initially feels bored and unhappy in her role as a homemaker. After Elliot has an affair which leads to divorce proceedings, Nancy develops a career as a children's book illustrator and author, and begins teaching at a local art center. Elliot becomes jealous after she also begins to date and finds himself once again attracted to her. Eventually, they rekindle their relationship and stop divorce proceedings. During the final two seasons, Nancy struggles with, but ultimately overcomes, ovarian cancer, which deepens their relationship. Always a rebel, Elliot can never reconcile himself to Miles' preference for Michael and his own loss of creative work at DAA, and eventually quits DAA in a fit of rage against both Miles and Michael. He and Nancy move to California, where he finds his passion in directing and eventually makes up with Michael when they accidentally bump into each other during Michael's job interview at TBWA\Chiat\Day. Michael does not accept the job but briefly entertains the possibility of working again with Elliot to make commercials (and turns again to Miles for help in this endeavor). At the time the show was canceled, it is implied that this venture will not happen after Michael tells Hope that he will stop working so that she can pursue her own interests.