Rosa Blasi as Dr. Luisa "Lu" Magdalena Delgado, born November 18, 1970. Delgado runs the free clinic (first the South Philly Health Clinic and, since the pilot, the Rittenhouse Health Center), and hosts a support group. Both as a friend and a doctor to many lower-class patients, Lu regularly comes face-to-face with bitterly ironic situations involving the difficulties of the lower class with government, debt, drug abuse, and exploitation. Her character exhibits a perennial cleverness which allows her to wheedle or persuade positive outcomes from seemingly hopeless cases of victimization. After her mother died of breast cancer when she was ten years-old, she was raised by her grandmother, Isabel Santana, who now lives in Puerto Rico. Lu has a son, Marc, who she had when she was 16 and raised alone. Until recently, Delgado has had no luck with a relationship. Her first boyfriend, Jack (Jeffrey D. Sams) a construction worker, dumped her, because he wasn't ready to get involved in a fatherly (or even father figure) relationship with Lu's son Marc. Lu's next boyfriend, radio show host Harry Burr (Don Michael Paul) had to leave her because his ex-wife was using their relationship to gain custody of his daughter Erin, who was also her son Marc's girlfriend. Soon after, she survived being raped by the Rittenhouse's new Head of Surgery, Dr. Randolf Kilner. She lost her first serious boyfriend, fireman Miguel "Mickey" Arenas (Julien Acosta), to a murder perpetrated by one of her patients, forcing her to face her moral objection to the death penalty. Ironically, in an earlier episode, Lu thought Miguel had died on the job, when there was a fire at the local mall. It turns out the only reason he didn't die, is because he switched duties with friend and ended up driving the fire truck. Lu later becomes involved with Ben Sanderson (Grant Show), an administrator brought on after Rittenhouse is bought by a health care conglomerate, Octavian Systems. Sanderson later left to be reassigned to a facility in Miami. He asked Lu to come with him but, after thinking about it, she refused because her patients are there, and the constant travel makes it difficult to put down roots. Soon after, she became involved with Jonas Rey (Nestor Carbonell), a local self-made millionaire with a good heart but a large soulless corporation. In the final season, she and Jonas get married, and Lu struggles to get accustomed to a wealthier life, while trying to reconcile it with her inner-city loyalties. After Lu discovered she was pregnant with Jonas' baby, Jonas is plagued by an embezzlement scandal at his company, bringing his fortune into doubt. In the series finale, they decided to move to Jonas' childhood home, but while he was showing it to Lu, they were affected by an explosion and got caught in the ruined basement. Lu was injured and her placenta detached. She asked Jonas to perform an emergency C-Section to save her and the baby, but she fainted during the procedure. Luckily, the firemen arrived and called Dylan, who completed the C-Section, and Lu gave birth to their daughter, who was named Milagro (which means "miracle" in Spanish).