Smiley has hosted many game show skits, such as:
Can You Guess? — a satire of To Tell The Truth — Three Muppets, a father, mother and son, each announce themselves as "the mother of this family", and Grover (then called "Billy Monster") has to guess which is the true mother. (The Smiley character was then named "Big Bob".)
Pick Your Pet — a blindfolded little girl Muppet, Betty Lou, must choose one of three animals (one a monster) as her own pet without being able to see any of them, after asking each of them how they would behave in her home as her pet and listening to their answers. (The Smiley character was then named "Sonny Friendly".)
The Mr. and Mrs. Game — the first skit in which the host was named Guy Smiley, this satire of The Newlywed Game featured a monster couple. The object was for the wife to guess her husband's favorite color, food and sport without being told in advance, after Betty Lou took him into a soundproof booth so he couldn't hear his wife's answers.
The Remembering Game — a spoof of Concentration, two contestants try to match prizes on a four-space board. In its one appearance, Cookie Monster and an Anything Muppet named Bill Smith didn't like the prizes they had "won", so they traded prizes after Cookie had won an airplane and Bill had won a cookie.
What's My Part? — a spoof of What's My Line? — Three blindfolded celebrities had to identify a body part before all three of them were disqualified (by asking a question that had a "no" answer). The first segment, featuring a nose, starred panelists Cookie Monster, Bennett Snerf and Arlene Frantic as noseless monsters. (The latter two were Muppet parodies of longtime What's My Line? panelists Bennett Cerf and Arlene Francis). None of them guessed right and the nose won the game. The second segment, featuring a foot, starred Snerf, Frantic, and Professor Hastings as Anything Muppets with human features. Professor Hastings won the game by accident after he complains his foot fell asleep.
What's My Letter? – Based on the sixth track from the 1971 Sesame Street record The Muppet Alphabet Album, this sequence featured Smiley challenging Prairie Dawn to guess a particular letter of the alphabet.
Get Wordy - a spoof of Jeopardy!, Smiley reads a meaning of a phrase and contestants have to guess what the phrase is.
Mystery Guest — a spoof of a term used on What's My Line? — The contestants, (Cookie Monster, Don Music and Sherlock Hemlock), must guess who the Mystery Guest is. In this clip, it was the letter X, but nobody guessed correctly, and it turned out that the letter X belonged in the exit sign. After the contestants left, The announcer blurts "You sure fooled them, X." It ran once.