德怀恩·辛特祖斯

Schintzius received athletic scholarship offers from many top college programs. Unlike most top Florida high school basketball prospects up to that point, he chose to stay in-state and attend the University of Florida, where he played for the Florida Gators men's basketball team from 1987 to 1990 under head coach Norm Sloan. Schintzius started at center for the Gators beginning early in his freshman season. By the end of his junior season (1988–89), he had led the Gators in scoring, rebounding, and free-throw percentage over at least one full season. He also set the program's record for blocked shots, and at the end of his junior year, his season blocked shot totals ranked first, second, and third in school history.

The Gators had never been invited to the NCAA basketball tournament in over seven decades of basketball. However, they made the field during each of Schintzius's three full seasons with the program and advanced to the Sweet Sixteen in 1987. During his junior year, the Gators won their first-ever regular season Southeastern Conference (SEC) championship. Schintzius was recognized as a first-team All-SEC player after that season and was included on multiple All-American lists.

However, Schintzius' college career was marred by disciplinary problems. He occasionally clashed with Coach Sloan, including one instance in which he refused to re-enter a game with a minute left during his sophomore season. He also had minor incidents with opposing players, fans, and mascots, and with others off the court.

During his junior season, Schintzius allegedly heard a rude remark from a sidewalk while riding in a car outside a Gainesville nightclub and stormed after the offender wielding a tennis racket. Schintzius later apologized and was not charged with a crime, but the university's office of student affairs found him guilty of violating the student code of conduct and suspended him for four games.

After returning from that suspension, fans in opposing arenas occasionally threw tennis balls onto the court, presumably taunting Schintzius for the incident. In January 1989, Florida traveled to Nashville to face the Vanderbilt Commodores in a crucial SEC matchup. Losing 72–70, Florida turned the ball over with only one second left on the clock, seemingly sealing a loss. But at that point, someone in the Memorial Gymnasium home crowd threw a tennis ball onto the court. Referee John Clougherty immediately called a technical foul on the Commodores, and Schintzius, who led the Gators in free throw percentage that season, hit both free throws to send the game into overtime. He then scored the Gators' first seven points in the extra period and Florida won the game 81–78. Florida went on to capture the program's first SEC regular season championship, beating Vanderbilt by a single game.

Sloan was forced to resign before Schintzius's senior season of 1989–90 and was replaced on an interim basis by former Tennessee coach Don DeVoe. Schintzius was not happy with this turn of events and skipped DeVoe's first practice with the team along with fellow star Livingston Chatman. Soon after, he was suspended for alleged involvement in a fraternity house fight. DeVoe told Schintzius that in order to rejoin the basketball team, he would have to improve his off-court behavior, maintain his playing weight (he weighed almost 300 pounds at one point), go to class consistently, and get rid of his distinct mullet-style haircut, known as the "lobster.". In a statement released January 25, 1990, Schintzius claimed that he had done all these things, but was nonetheless quitting the team due to conflicts with his new coach. The statement read, in part:

No one can argue that Coach Sloan and Coach Towe (Monte Towe, Sloan's assistant) were easy to play for, and to them you had to accept the coach as the absolute authority and their word as final; but that does not mean I must sail under the authority of Captain Ahab. If you can play for Coach Sloan, you can play for almost anyone, almost anyone.

Without Schintzius, the Gators lost sixteen of the seventeen games to end the season and missed the NCAA tournament for the first time since the year before his arrival.

Schintzius remains the only player in SEC history to amass more than 1,000 points, 800 rebounds, 250 assists and 250 blocks. He still holds Florida's career record for blocked shots (272), and ranks sixth among the program's all-time scoring leaders with 1,